GAD2 and type 2 diabetes mellitus: In 2010, a large clinical trial named Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) screened 1,206 children with T2DM for GAD-65 and insulin-associated protein 2 autoantibodies and reported that 5.9% of the patients were positive for one antibody and 3.9% for both of them [13].