In patients with triple-negative breast cancer (TNBC), the Clostridiales-related metabolite trimethylamine N-oxide (TMAO) was found to induce pyroptosis in tumor cells by activating the endoplasmic reticulum stress kinase PERK, thereby enhancing CD8+ T cell-mediated antitumor immunity (Wang et al., 2022). This evidence concerns the gene CD8A and neoplasm.