Differences in pituitary insufficiency were present between the treatment groups: TSH deficiency was seen in 11%, 67% and 41% and LH/FSH deficiency was seen in 10%, 83% and 48% of patients with anti-PD-(L)1 versus, anti-CTLA-4 and anti-CTLA-4/PD-1-induced hypophysitis, respectively. This evidence concerns the gene CD274 and central congenital hypothyroidism.