In one study, the prevalence of thyroid-stimulating hormone (TSH) deficiency and luteinizing hormone (LH)/follicle-stimulating hormone (FSH) deficiency was found to be higher in anti-CTLA-4-induced hypophysitis than in anti-PD-(L)1-induced hypophysitis, 85% and 75% versus 4% and 13%, respectively (9). This evidence concerns the gene PLOD1 and central congenital hypothyroidism.