In accordance to the prevalence of hormone deficiencies, the median levels of TSH, LH, FSH and testosterone were significant lower in patients treated with anti-CTLA-4 and anti-CTLA-4/PD-1-therapy No differences were seen in prevalence of ACTH deficiency, hyponatremia and IGF-1 level ≥2 SD below the reference range. The gene discussed is BRD2; the disease is Hyponatremia.