Differences were seen both in timing and in the degree of hypophysitis; anti-PD-(L)1 induced hypophysitis was seen after a median of 21.9 weeks versus after 10.6 and 13.9 weeks in patients with and CTLA-4 and anti-CTLA-4/PD-1 induced hypophysitis. This evidence concerns the gene CTLA4 and hypophysitis.