After treatment, the TCRbhiPD‐1hiCD69+CD27+ CD8+ Teff decreased in proportion in the HB group, while the proportion of Ly6ChiTCRb+CD69+CD27+CD62L+ CD8+ Tcm increased, underscoring the enhanced ability of the immune system to effectively eradicate tumor cells. The gene discussed is CD27; the disease is neoplasm.