Since CXCL2 is involved in the development of cardiovascular diseases through its role as an important inflammatory chemokine,19 we next performed immunostaining of CXCL2 in the ischemia brain at 1 day after MCAO and found that infiltrating neutrophils were the predominant producers of CXCL2 followed by microglia, and neurons (Figure 4A,B). Here, CXCL2 is linked to cardiovascular disorder.