AIF1 and Alzheimer disease: Lastly, to clear up the conflicting reports implicating IBA1 changes in AD [12], we show the levels of IBA1 correlate with important disease characteristics, such as age at onset (AAO), age at death (AAD), the insoluble Aβ(1–42)/Aβ(1–40) ratio, and the soluble Aβ(1–42)/Aβ(1–40) ratio in a sex-dependent manner.