LINC00460 was first reported by Lian et al. in 2018 to affect the proliferation and apoptosis of CRC cells by inhibiting KLF2 transcription via binding to an enhancer of EZH2 and acting as a ceRNA for miR-149-5p and unblocking its inhibition of CUL4A [48]. The gene discussed is CUL4A; the disease is colorectal carcinoma.