These pathways were also the top five enriched pathways in the R group of the eight internal HGSOC samples (Fig. 2): oxidative phosphorylation in the tumor and stromal regions, TNF-α signaling via NF-κ in the tumor region, G2/M checkpoint, E2F target, and MYC target V1 in the stromal region. Here, MYC is linked to neoplasm.