A wide study of epidemiological cohorts showed that a biomarker-based risk score including NT-proBNP (cut-point ≥ 125 pg/ml) together with high-sensitivity cardiac troponin-T, high-sensitivity C-reactive protein and electrocardiographic-based LVH based on Sokolow-Lyon criteria, was able to predict diabetic and pre-diabetic patients at higher 5- and 10-year HF risk [36]. The gene discussed is NPPB; the disease is hydrops fetalis.