By Spearman’s test, NT-proBNP significantly and directly correlated with age (r = 0.526, p < 0.001), T2DM duration (r = 0.179, p = 0.015) and pulse pressure (r = 0.166, p = 0.031), while inversely correlated with eGFR (r = − 0.368, p < 0.001), BMI (r = − 0.202, p = 0.023), waist circumference (r = − 0.160, p = 0.028) and TyG index (r = − 0.234, p = 0.013). The gene discussed is NPPB; the disease is type 2 diabetes mellitus.