Although the role of the TREM2-DAP12 receptor complex in lung cancer progression is unknown, our findings elucidated that TREM2 or DAP12 deficiency inhibited lung cancer progression in vivo (Supplementary Fig. 4A and 4B), suggesting that TREM2 affects lung cancer progression through the adaptor molecule, DAP12. Here, TREM2 is linked to lung carcinoma.