Similarly, ELISA results showed consistently increased granzyme B and perforin in the tumor-grinding fluid of mice injected with TREM2 KO monocytes (Fig. 6B), indicating that TREM2 promotes tumor growth in vivo by increasing the number of M2-TAMs and inhibiting the anti-tumor function of CD8+ T and NK cells. This evidence concerns the gene TREM2 and neoplasm.