Flow cytometric analyses of tumor-infiltrating immune cells showed that the proportion of macrophages was decreased in TREM2f/f-Lyz2-Cre mice; however, the percentages of CD8+ T and NK cells were increased compared to those in WT mice, and were further decreased or increased in combination with GB1107 treatment, respectively (Figs. 7J and 8A). Here, CD8A is linked to neoplasm.