Under normal physiological conditions, the estrogen receptor (ER)/amplified in breast cancer 1 (AIB1)/ANKRD11/HDACs or transcriptional enhanced associate domain (TEAD)/yes-associated protein (YAP)/AIB1/ANKRD11 complex functions to suppress the transcriptional activation of oncogenes in breast cancer [11, 12]. This evidence concerns the gene ESR1 and breast cancer.