Germline pathological variants, such as ATM, BRCA1, BRCA2, CHEK2, and PALB2, which are known to cause homologous recombination deficiency (HRD), have been reported to be present in 10–20% of patients with PC [11–13]. Here, CHEK2 is linked to hypoparathyroidism-retardation-dysmorphism syndrome.