Administering these inhibitors for eight weeks exhibited beneficial effects through reduction of thyroid volume, lymphocyte infiltration, serum TGAb, TPOAb and TSH levels, and attenuation of Caspase-1, IL-1β expression without impacting the expression of USP1 or inflammasomes upstream of pyroptosis (Fig. 5B–I), signifying the importance of TFCs' pyroptosis in HT development. This evidence concerns the gene IL1B and hematocrit.