It is worth mentioning that Zhong et al. used an experimental model system originally designed to define how hr-IGF1-IGFBP-3 affected the development of NEC in pre-term pigs.4 In their model, NEC develops spontaneously due to the preterm delivery by cesarean section plus the formula feeding, following the occurrence of hypothermia and hypoxia in the immediate neonatal period. The gene discussed is IGFBP3; the disease is necrotizing enterocolitis.