AD STAT3 HIES (c. 1145 G>A) diagnosed at 2 y/o. Her highest recorded IgE is 36,307 IU/dl, and highest recorded eosinophil count 330 cells/μl. Clinical infectious history of recurrent skin abscesses, eczema, mucocutaneous candidiasis, recurrent sinopulmonary infections with pneumatocele formation, and an episode of bacterial sepsis. There is also noninfectious history of retained primary teeth, mild scoliosis, and recurrent minimal trauma fractures. The gene discussed is IGHE; the disease is bacterial infectious disease with sepsis.