7 y/o African American male with AD STAT3 HIES (c.1144C>T) diagnosed at one y/o. His highest recorded IgE is 9,020 IU/dl, and highest recorded eosinophil count 1,500 cells/μl. Clinical infectious history of recurrent skin abscesses with both MRSA and MSSA, mastoidosis with subdural empyema, and pneumonia. There is also noninfectious history of newborn rash and eczema. This evidence concerns the gene IGHE and subdural empyema.