AD STAT3 HIES (c. 1144 C-T) diagnosed at 21 y/o. Her highest recorded IgE is 3,880 IU/dl, and highest recorded eosinophil count 1,440 cells/μl. Clinical infectious history of recurrent skin abscesses, newborn rash, eczema, mucocutaneous candidiasis, shingles as a teenager after natural infection, recurrent sinopulmonary infections with pneumatocele formation, noninfectious history of retained primary teeth and mild scoliosis but no fractures, and history of lymphoma. Here, IGHE is linked to Alzheimer disease.