AD STAT3 HIES (c.1144C>T) diagnosed at 7 y/o with, at that time, IgE 1,850 IU/ml; AEC 606 cells/μl; and a clinical history of pneumonia, two episodes of MRSA boils of the skin, recurrent fungal fingernail infections, mild eczema, two retained primary teeth, and three episodes of minimal trauma fractures. He now has recurrent skin abscesses, bronchiectasis, and inflammatory bowel disease. The gene discussed is IGHE; the disease is Alzheimer disease.