AD STAT3 HIES (genetic testing report not available) diagnosed based on clinical symptoms at 2 yr of age which included recurrent MSSA skin abscesses, IgE 3,970 IUI/ml, AEC 664 cells/μl with confirmatory genetic testing performed at age 12 years. She now has difficulty with recurrent polymicrobial skin abscesses, particularly of the breast, requiring hospitalization and surgical drainage; recurrent vaginal candidiasis; mild bronchiectasis with small pneumatoceles; and eczema which is controlled with dupilumab. This evidence concerns the gene IGHE and Alzheimer disease.