BID and ischemic stroke: In ischemic stroke, elevated chondriosomal Ca2+ levels result in the cleavage of BH3 interacting-domain death agonist (BID) into truncated BID (tBID), which interacts with B-cell lymphoma 2 (BCL2) antagonist/killer 1 (BAK), an apoptotic protein, at the mitochondrial membrane.