It was observed that the T alleleand CT and TT genotypes, in the dominant model of the rs1799854variant in the ABCC8 gene, were significantly associated with therisk for developing type 2 diabetes and could be considered a good genetic marker instudies related to type 2 diabetes, both in admixed populations of the BrazilianAmazon and in native populations. Here, ABCC8 is linked to type 2 diabetes mellitus.