In this sense, this study aims to investigate the association of risk variants inSNPs (rs4994) in the ADRB3 gene;(1799854) in the ABCC8 gene;(rs7901695 and rs12255372) in theTCF7L2 gene, and (rs8050136) in theFTO gene with type 2 diabetes (T2D) in a sample of thepopulation of Santarém, in the state of Pará, in the North Region of Brazil, knownas the Amazon Region, where the rates of T2D are high. The gene discussed is ABCC8; the disease is type 2 diabetes mellitus.