In this study, the association of SNPs ADRB3(rs4994), ABCC8 (rs1799854),FTO (rs8050136), and TCF7L2(rs7901695 and rs12255372) with T2D wasinvestigated in an admixed Amazonian population from the interior of the NorthRegion of the state of Pará, in the city of Santarém. Here, ADRB3 is linked to type 2 diabetes mellitus.