STAT3 and glioblastoma: Consistent with the findings reported in GBM stem cells, Western blot analysis for STAT3 phosphorylation levels (pSTAT3-Tyr705) in either control or BMX-IN-1–treated NB1 and NB4 spheroids confirmed a marked reduction in pSTAT3 levels upon BMX inhibition (Supplemental Figure 2L).