MYCN and colorectal carcinoma: These findings held true when we restricted the gene signatures to CRC-TFs responsible for maintaining the cell identity of MES and NOR cells in NB (Figure 6A and Supplemental Figure 3A) (43).This trend was particularly evident in nMNA tumors, as compared with MNA tumors, consistent with a more prevalent role for BMX in shaping cellular phenotypes in the absence of MYCN amplification.