In context of cancer cell and T cell crosstalk, SETDB1 mediates intrinsic immunogenicity of cancer cells by catalyzing H3K9 trimethylation and repressing IFN genes (45); HDAC8 in hepatocellular carcinoma cells inhibits CD8+ T cell infiltration by reducing H3K27 acetylation and silencing chemokine gene CCL4 (26); and MLL3 and MLL4 ablation in cancer cells promotes CD8+ T cell activation and cytotoxicity by decreasing H3K4me1 and H3K27ac marks and inhibiting GSDMD expression (46). The gene discussed is KMT2C; the disease is cancer.