IDH1 and cancer: Although many studies have focused on elucidating the relationship between cancer cell genetic alterations (e.g., mutation and deletion of IDH, PTEN, TP53, NF1, and RB1) and TAM biology (59–62), recent findings suggest that epigenetic reprogramming also regulates the biology (e.g., infiltration and immunosuppressive polarization) of TAMs (20, 57).