Additionally, pharmacologic inhibition of other methyltransferases (e.g., PRMT5, SMYD3, or MLL4 methyltransferase) or specific deletion of these epigenetic regulators in cancer cells has also been found to specifically increase the antitumor efficacy of anti-PD1 therapy across cancer types (46, 137–140). The gene discussed is SMYD3; the disease is cancer.