CHRNA7 and psychotic disorder: These findings generally align with a proposed working model of low α7-nAChR availability in the hippocampus of patients with psychotic conditions, wherein characteristic signs of the conditions are caused by low activity of the α7-nAChR on GABA-ergic interneurons that disinhibit excitatory inputs to glutamatergic pyramidal cells.10 We note that while we focused on hippocampus, results from secondary ROIs and parametric images of [18F]ASEM VT support a more diffuse, low availability of the α7-nAChR in recent-onset psychosis, particularly in NP.