Related studies have shown that miR-205-5p plays a regulatory role in epithelial‒mesenchymal transition by targeting PTEN via the PI3K/AKT signaling pathway in cisplatin-resistant nasopharyngeal carcinoma cells [34], and miR-205-5p inhibits PTK7, thereby affecting the proliferation, migration, and invasion of CRC[35]. Here, AKT1 is linked to colorectal carcinoma.