ALDH1A2 and helminthiasis: In type 2 inflammation, ALDH1a2 in human basophils mediates an allergic response (Spiegl et al., 2008), or ALDH1a2 induction in alternatively activated macrophages helps mount a Th2 response during helminth infection (Broadhurst et al., 2012; Kannan et al., 2016).