WIN18446 has also been shown to be a potent antiobesity treatment due to its inhibition of ALDH1a1, although hepatic lipidosis is a side effect of the drug that is not witnessed in ALDH1a1 knockout mice (Haenisch et al., 2018) or disulfiram-treated mice (Bernier et al., 2020). This evidence concerns the gene ALDH1A1 and fatty liver disease.