Interestingly, ALDH1a2 RNA amplification is necessary for LMO1-fusion T cell acute lymphoblastic leukemia (T-ALL) transformation (Ono et al., 1998; Zhang et al., 2021), showing that atRA has unique autocrine cancer effects in this specific T cell leukemia. The gene discussed is ALDH1A2; the disease is acute lymphoblastic leukemia.