Tumour SDHB immunohistochemistry (IHC) is a widely used technique that helps triage SDHx genetic testing (Gill et al. 2010, Castelblanco et al. 2013, Papathomas et al. 2015); as noted above, loss of SDHB staining occurs from genetic disruption of any of the SDHx genes. Here, SDHB is linked to neoplasm.