NLR is a protein family consisting of 22 members, all of which possess three structural domains and play important regulatory roles in mediating tumor inflammation response.24 Previous studies have shown that the activation of NLR is closely associated with various types of cancer, such as HCC, breast cancer and colorectal cancer.25 As the largest protein in the NLR family, NLRC5 plays a crucial role in innate immunity in eukaryotes. This evidence concerns the gene NLRC5 and colorectal cancer.