Consistent with these findings, Muir et al,47 identified that stearoyl-Co-A desaturase (SCD), the rate-limiting enzyme in the conversion of saturated fatty acids (SFAs) to MUFAs, which is preferentially found on the endoplasmic reticulum, was upregulated in human NAFLD-related HCC samples and Pten-null NASH-HCC murine models. The gene discussed is SCD; the disease is metabolic dysfunction-associated steatotic liver disease.