An increased expression of SAV1, a protein necessary for the function of Mst1/2 upstream in the Hippo tumor-suppressive pathway, is associated with favorable prognosis in HCC (Figure 2E), whereas, reciprocally, the expression of BIRC5 and TEAD2 has been associated with poor overall survival in HCC (Figure 2F and G). The gene discussed is SAV1; the disease is hepatocellular carcinoma.