Using an intratumoral delivery of Ad5CMV-p53 in patients receiving sequential therapy of cisplatin and p53 gene therapy enhances p53 expression. This was confirmed via tumor biopsies showing an increase of 79% in cell apoptosis.Same showed in p53 injections with concomitant radiotherapy. In biopsies obtained 3 months after therapy, no viable tumor was observed in 63% of cases. The gene discussed is TP53; the disease is neoplasm.