Moreover, eukaryotic translation initiation factor 3 subunit A (EIF3A), DDX21, SDE2, transportin 1 (TNPO1), and ring finger protein 40 (RNF40) are thought to mediate multiple alternative splicing events in bladder cancer, implying their essential roles in the development and progression of this disease (114). This evidence concerns the gene RNF40 and urinary bladder cancer.