One of the best-studied anti-inflammatory cytokine families is the interleukin-10 (IL-10) superfamily—a group of highly pleiotropic cytokines and their associated receptors—which can act via activation of Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling, a central component in host defense during infection or injury [1]. The gene discussed is IL10; the disease is infection.