Serum S100A12 levels were significantly higher in FMF patient group than in both the JIA and control groupsNon-significant increase of S100A12 levels in the attack period compared to the attack-free periodS100A12 levels dropped dramatically after administration of colchicine therapy but no correlation was detected between S100A12 levels and FMF activity. The gene discussed is S100A12; the disease is familial Mediterranean fever.