IL-1RA VNTR A1/A2, A1/A4 genotypes and A1A4 alleles as well as the MIF (−137G/C) polymorphism exhibited higher frequency in both patient groups compared to controlsIL-4 VNTR P1 allele was more common in FMF patients with amyloidosis compared to controls; however, no significant difference was observed between groups of FMF patients. The gene discussed is MIF; the disease is familial Mediterranean fever.