Both polymorphisms showed no significant difference in genotype and allele distribution between patients and controlsPatients with TNF-α −308 GG are more susceptible to develop amyloidosis and arthritis whereases TNF-α −308 A may have a protective role among M694V homozygous patients with amyloidosisTNF-α (−1,031 T/C) did not reveal a significant correlation with the manifestation and progression of clinical characteristics of FMF. This evidence concerns the gene TNF and familial Mediterranean fever.