IL-1β was assessed in another research, along with IL-18 and caspase-1, in the serum of 60 FMF patients (30 in attack and 30 free of attacks) and 30 healthy controls using ELISA with the main purpose to investigate the possible relationship of these markers with disease severity and acute phase reactants in FMF (57). The gene discussed is IL1B; the disease is familial Mediterranean fever.