Datarevealed that NKX2-5 variations have been identified as a genetic modifier in cases of LVNC cardiomyopathy, where the age at whichsymptoms manifest might range from childhood to the incidental discovery of asymptomatic cases in adults, whereas in hypoplastic leftheart syndrome (HLHS) patients, NOTCH1 gene mutations have been identified in iPSCs derived from these patients [52].A set of differentially expressed genes (DEGs) in HLHS was significantly enriched in these heart failure coordinators. The gene discussed is NKX2-5; the disease is hypoplastic left heart syndrome.