Our IVW findings suggested a positive correlation between levels of SDF_1A and B-NGF and the occurrence of SCLC (SDF_1A: OR: 1.13, 95% CI: 1.05-1.21, p=0.001; B-NGF: OR: 1.13, 95% CI: 1.01-1.27, p=0.029). This evidence concerns the gene NGF and small cell lung carcinoma.