The comparison between the two study groups regarding PTEN genotypes and allele frequencies, showed lower frequencies of wild genotype TT with equal frequencies of heterozygous mutant genotype TC and higher frequency of homozygous mutant genotype CC in CRC patients versus controls with non-significant p. value (10%, 60% and 30% versus 12%, 60% and 28% respectively, p < 0.918). The gene discussed is PTEN; the disease is colorectal carcinoma.