CXCL1 and hepatocellular carcinoma: In addition, overexpression of CXCL1 in HepG2 and HepG2/C3A cells (which have the lowest CXCL1 expression) or the knockdown of CXCL1 in Huh7 and Hep3B cells (which have the highest CXCL1 expression), respectively, promoted and reduced ICAM-1 protein expression in hepatocellular carcinoma cells (Figure 6C).