By employing algorithms such as MNC, Degree and MCC of CytoHubba, 8 core targets were identified as focal in NPC modulation, including AKT1, CTNNB1, HSP90AA1, BCL2, STAT3, CASP3, ESR1, and MMP9 (Fig. 6B). Here, ESR1 is linked to nasopharyngeal carcinoma.