According to the clinical tissue samples analysis provided by the GEPIA2 tool, SMAD4-213 transcript has higher expression in colon and rectal adenocarcinoma (2.28 Transcripts Per Million - TPM and 2.22 TPM) in comparison to healthy colon and rectum tissue (0.62 TPM and 0.49 TPM), which is in line with our analysis. The gene discussed is SMAD4; the disease is rectum adenocarcinoma.