In a subsequent analysis of COA6 gene expression in distinct clinical subgroups of breast cancer cases in TCGA, no significant differences were detected in COA6 mRNA levels across ages, genders, N (lymph node metastasis) stages, and M (distant metastasis) stages (Figure 2A, 2B, 2D and 2E). Here, COA6 is linked to metastatic malignant neoplasm in the lymph nodes.