OTOP2 and cancer: Significant alterations in OTOP2 mRNA expression were observed in the 10 total tumor samples and their corresponding normal samples from various cancers within the TCGA Pancancer database, including COAD (P<0.001), HNSC (P<0.05), KICH (P<0.01), kidney clear cell cancer (P<0.01, KIRC), kidney papillary cell cancer (KIRP, P<0.01), liver hepatocellular carcinoma (LIHC, P<0.05), lung squamous cell cancer (LUSC, P<0.001), READ (P<0.01), stomach adenocarcinoma (STAD, P<0.01), and UCEC (P<0.05), (Supplementary Figure 1B).