Specifically, the high ELF4 expression subgroup was endowed with high immune activity and tumor invasiveness phenotype, characterized by the elevated activity of Il6 Jak Stat3 signaling, TNFA signaling Via NFκB, interferon alpha response, IL2/Stat5 signaling, Myc targets, epithelial-mesenchymal transition (EMT), angiogenesis, and DNA repair (Fig. 4D). Here, TNF is linked to neoplasm.