ELF4 and central nervous system cancer: In addition to the role of ELF4 in modulating RTK signaling and lipid dynamics, as well as glioma malignancy12, 13, 32, the present research further provided insights into the epigenetic regulation of ELF4 and the influence of ELF4 on glioma outcomes, TAMMs infiltrate and sensitivity to veliparib, motesanib, and EHT 1864 in glioma samples.