The expression of SOX12 is correlated with the malignancy of HCC (such as extracapsular invasion, microvascular invasion, and lymph node metastasis), and higher SOX12 levels are associated with poorer prognosis in HCC patients (overall survival P = .0004, progression-free survival P = .0013).44 The gene discussed is SOX12; the disease is hepatocellular carcinoma.