CLSTN3 and Cirrhosis: CLSTN3 was reported to be upregulated in patients with hepatocellular adenoma compared with that in patients with HCC, and CLSTN3 was recognized to be involved with the difference in the degree of HCV-related cirrhosis (in the common term between; F2 vs F4 and F3 vs F4, F1 vs F3).32