In the methylation analysis, we observed a potential functional role of hypomethylation in 8 HCV-related HCC that affected their genes (TRIM54, TENM2, APBB1IP, SNX19, CLSTN3, OAS1, IRX5, and SOX12) between the NR and ER groups in common between the 2 sets (Table 3). Here, IRX5 is linked to hepatocellular carcinoma.