,45 Specifically, SOX12 activates the expression of Twist1 and fibroblast growth factor–binding protein 1, which promote the epithelial-mesenchymal transition of HCC and increase the expression of CDK14 and insulin-like growth factor 2 mRNA-binding protein 1, defining the malignant phenotype of HCC.44 The gene discussed is IGF2; the disease is hepatocellular carcinoma.