The main findings of our meta-analysis on use of vasoconstrictors with intravenous albumin in the treatment of HRS-AKI are that (a) terlipressin and nor-epinephrine are similar and superior to midodrine and octreotide for reversal of HRS, (b) higher serum creatinine and MELD score at baseline are associated with lower odds of HRS reversal, and (c) these drugs especially terlipressin and norepinephrine should be used judiciously with close monitoring for cardiopulmonary or ischemic adverse events. This evidence concerns the gene ALB and acute kidney injury.