Specifically, the immunoexpression of three autophagy-related proteins (Beclin-1, p62, and ATG7) has been evaluated in a series of uveal melanomas, with an overexpression of Beclin-1 that documented a relationship with histotype and better outcome; by contrast, no significant differential expression of ATG7 and p62 between patients, with or without metastasis, has been reported [3]. The gene discussed is SQSTM1; the disease is uveal melanoma.