SQSTM1 and meningioma: Consequently, the presence of these intranuclear vacuoles strongly support the idea that macroautophagy takes place in meningiomas, although only ultrastructural observations have been performed in 15 cases [30], while p62 protein has been documented as possible predictor of malignancy in a series of 45 benign meningiomas, exclusively from female patients [29].