Immunohistochemical staining results for the five genes obtained from the Human Protein Atlas database revealed that the tumor group displayed notably higher protein expression levels of KIFC2, TFRC, SMYD2, and OPN3 than the normal group (http://www.proteinatlas.org/) (Fig. 5C); conversely, ASMTL was downregulated in the tumor group when compared to that in the normal group. The gene discussed is OPN3; the disease is neoplasm.