It may also explain why IgG4-RD has ectopic and heterochronic pathogenesis; several autoantigens, such as prohibitin,7 galectin-3,8 and laminin 5119 have been reported to involve in the pathogenesis of IgG4-RD, and these are not specific to the pancreas or salivary glands. This evidence concerns the gene LGALS3 and immunoglobulin G4-related sclerosing disease.