GPT and metabolic syndrome: ,17,31,38,42 In the PIVENS trial, factors associated with higher odds of NASH resolution included reductions in alanine aminotransferase (ALT) and aspartate aminotransferase (AST; vitamin E and pioglitazone arms), lower baseline metabolic syndrome (MetS) severity Z-score (MetS-Z; vitamin E and pioglitazone arms), and reductions in MetS-Z (placebo arm).31