The most prevalent factors associated with fibrosis progression or advanced fibrosis stage across the studies were higher NFS/change in NFS,15,18,42,45 higher AST:ALT ratio,18,46 ALT normalization/nonresponse,42,43 higher AST-to-platelet ratio index,15,45 higher fibrosis-4,15,18 lower platelets/change in platelet count,15,42,47 and T2D.18 This evidence concerns the gene GPT and type 2 diabetes mellitus.