NLRP3 and chronic obstructive pulmonary disease: While numerous inflammasomes exist (NLRP1, NLRP2, etc.)(14–17), NLRP3 has received significant attention due to its potential involvement in various diseases, including allergic diseases, chronic obstructive pulmonary disease (COPD), and cryopyrin-associated periodic fever syndromes (CAPS) (6, 13).