demonstrated that house dust mites (HDMs) extracts inhalation in mouse models activated NLRP3 inflammasomes in the lungs, specifically inducing the maturation of caspase-1 and IL-1β in alveolar macrophages (AMs), a critical factor in pulmonary type II immune response inflammation and tissue damage in asthma (104). Here, NLRP3 is linked to asthma.