NLRP3 and asthma: studied by establishing a mouse model of toluene diisocyanate (TDI)-induced experimental asthma, in which experimental data showed that bronchial epithelial cell pyroptosis was induced by NLRP3 inflammasome activation and cleavage of GSDND, to exacerbate TDI-induced airway inflammation and hyperresponsiveness in asthma (115).