In addition, it has been shown to participate in the prognosis and treatment of NLRP3-related diseases by directly targeting NLRP3, as demonstrated in mouse models of traumatic brain injury and myocardial infarction, where it has been found to reduce inflammation, prevent neuronal apoptosis, maintain the blood-brain barrier, alleviate neurological deficits, inhibit myocardial fibrosis, reduce infarction size, and improve cardiac function (145, 146). Here, NLRP3 is linked to Myocardial fibrosis.