Moreover, this suggests that iRhom2 may be a novel and key regulator of multiple keratins in epithelial tissues and links iRhom2 to the sporadic setting, given that Keratin 17 staining in TOC esophageal tissue matches previously reported staining patterns in sporadic ESCC.34 The gene discussed is RHBDF2; the disease is esophageal squamous cell carcinoma.