These 71 genes were then filtered across the 3 sporadic ESCC vs normal RNA-Seq datasets, revealing a suite of 22 transcriptional changes, 21 downregulated, including CRISP3, IL36A, and PSCA, and 1 upregulated, KRT17 (further information regarding these genes is described in Table A3). This evidence concerns the gene IL36A and esophageal squamous cell carcinoma.