It is known that iRhom2 is associated with p63 activity in stressed epidermal keratinocytes7; however, our analysis did not predict p63 gene targets to be transcriptionally dysregulated in either TOC 1 or TOC 2 (or ESCC) samples (Figure 3D), suggesting differences between skin and esophageal tissue in TOC. Here, TP63 is linked to esophageal squamous cell carcinoma.