FGFR2 and neoplasm: Furthermore, Wahiduzzaman et al. demonstrated that knocking out the NF2 gene in malignant pleural mesothelioma led to rising levels of fibroblast growth factor receptor 2 (FGFR2), which in turn up-regulated the cloning and migration activity of tumor cells, suggesting FGFR2 as a potential therapeutic target [36].