Given the primary role of the dopaminergic rewarding process in appetite modulation, it has been shown that genetic variants of dopamine-related enzymes, namely, the fat mass and obesity-related (FTO) gene and the monoamine oxidase A (MAO-A) gene, might be associated with palatable food and, therefore, with obesity physiopathology (Fuemmeler et al., 2008; Qi et al., 2014; Dias et al., 2016; Krishnan et al., 2017). Here, FTO is linked to obesity due to melanocortin 4 receptor deficiency.