Furthermore, KEGG pathway analysis revealed that MRGs were predominantly associated with carbon metabolism, biosynthesis of amino acids, valine, leucine and isoleucine degradation, PPAR signaling pathway, alanine, aspartate and glutamate metabolism, arginine and proline metabolism, butanoate metabolism, one carbon pool by folate, and arginine biosynthesis (Figures 2A, B), the aberrations of which are pivotal drivers in carcinogenesis and cancer progression. This evidence concerns the gene PPARA and cancer.