Previous research has shown that S. pyogenes can invade the joint microenvironment, and be a step in the development of septic arthritisLe Hello et al., 2009Volzke et al., 2020inoculated mice intravenously with S. pyogenes and observed septic arthritis 3~20 days after infection with increased levels of interleukin (IL)-1β and IL-6 in the joints along with an increased amount of nuclear factor (NF)-κB receptor activator ligand, which is a key cytokine for osteoclast formation. Here, IL6 is linked to infection.